Update on Peptides and New Salmon DNA Cosmetic Treatment

As the field of peptides continues to evolve, with new peptides emerging and new indications being discovered for existing ones, Dr. Dominique Fradin-Read saw the value in introducing two new peptides now available at VitaLifeMD. She will also review their key benefits and potential use as anti-aging agents.

Two New Peptides

The CB4211 peptide has gained significant attention in the scientific community for its potential therapeutic benefits. 

This synthetic peptide is designed to mimic natural biological processes, offering promising applications across various medical fields. CB4211 is a modified version of MOTS-c, a mitochondrial-derived peptide that regulates metabolic homeostasis and protects against metabolic stress. This enhanced version provides more potent and broader therapeutic options.

CB4211 is crucial for energy production at the cellular level.  It enhances mitochondrial function and stimulates ATP production by improving the efficiency of the electron transport chain. 

  • The peptide exhibits strong anti-inflammatory properties, helping to treat chronic inflammatory conditions; it acts as an antioxidant, preventing oxidative stress-related damage in cells.

CB2411 improves muscle function and increases physical performance as demonstrated in numerous studies. The benefits are:

  • Improved muscle mitochondrial function and higher level of energy 

  • Increased endurance in trained athletes

  • Enhanced strength even in patients diagnosed with muscular dystrophy 

  • Reduced muscle atrophy 

CB2411 supports fat loss in weight management programs. By acting at the mitochondria level, this peptide increases energy expenditure and improves metabolic rate. 

  • Research in Nature Communications demonstrated enhanced glucose uptake and insulin sensitivity. This can provide support for patients trying to lose weight that need metabolic optimization. 

  • Studies in Cell Metabolism showed significant fat loss and improved metabolic health in obese mice treated with CB4211. This makes CB2411 a good alternative for people engaged in weight loss programs who cannot take GLP1 or other modalities of treatments.   

Several studies have demonstrated the benefits of CB2411 in cardiovascular protection and support of healthy endothelial function

  • A study in the Journal of the American Heart Association revealed that CB4211 peptides improved endothelial function in a mouse model of cardiovascular disease. It reduced atherosclerotic plaque formation, highlighting the potential of peptide in preventing cardiovascular diseases.

  • Research published in Circulation Research demonstrated its ability to lower cholesterol levels and reduce systemic inflammation.

CB4211 enhances neuronal survival, making it a promising treatment for neurodegenerative diseases.

  • A study in Neurobiology of Aging showed reduced amyloid-beata accumulation in a mouse model of Alzheimer's disease.

  • Research in Brain Research demonstrated improved motor function and reduced dopaminergic neuron loss in a Parkinson's disease models

 For all these reasons the peptide CB2411 is emerging as a great support to prevent chronic diseases linked to aging and should be considered in any anti-aging approach to health.  

The GHK peptide is a bioactive peptide naturally present in human plasma, saliva, and urine. This tripeptide is synthesized within the body and plays critical roles in various physiological processes. It mainly helps to stabilize and deliver copper. When GHK binds with copper ions, it forms GHK-Cu, a complex known as copper peptide. Since its discovery in 1973 GHK-CU has established itself as a powerful protective and regenerative ingredient mainly used for wound healing and skin rejuvenation. It is currently widely used in skin and hair products. 

New research shows that the GHK peptide presents broader support at the gene level and can affect gene expression in a number of ways:

  • GHK increases the expression of 14 antioxidant genes resulting in a potent antioxidant effect, GHK expresses strong anti-inflammatory action by suppressing two prooxidant genes and modifying several genes involved in the inflammatory process. 

  • GHK appears to support the remodeling and restructuring of connective tissue, modulating expression of numerous genes, including up-regulation of genes of the TGF-β pathway. It increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. GHK’s ability to improve tissue repair has been demonstrated for skin and hair in several studies.

  • GHK can restore the function of lung fibroblasts in COPD patients and can protect lung tissue from acute lung injury 

  • GHK is a neuroprotector: it promotes nerve growth by activating the production of neurotrophic factors, which can help protect against oxidative damage. It prevents neurons degeneration under oxidative stress and has proven to help with anxiety and depression in animal studies.

A major concern for any substance, that activates cell growth and tissue remodeling, is whether it can also increase or not the risk of cancer. What is very reassuring about the GHK peptide is that it possesses potent anti-cancer properties. Various studies confirmed the findings that GHK affected 84 genes associated with DNA repair and other processes, relevant to anti-cancer effects. It also stimulated apoptosis, the mechanism of programmed cell death that occurs when a cell's DNA and the cellular skeleton break down, leading to the cell's death. It's a normal process that helps the body get rid of damaged or unneeded cells and plays a role in preventing cancer. For all these reasons it appears that the GHK peptide could be a protective agent for those exposed to toxins.

The novel observation that GHK might target an epigenetic pathway further enhances its potential as an anti-aging peptide. GHK peptide (with or without CU) ability to reset gene expression patterns to a healthier state may be a useful preventative measure and treatment for various conditions associated with aging. 

Salmon DNA Extracts for Skin Rejuvenation

Always looking for innovative anti-aging treatment to support natural beauty, Dr. Dominique Fradin-Read is very excited to introduce a new noninvasive cosmetic procedure now offered at VitaLife-MD. It sounds like this treatment could be a fascinating new approach to skin rejuvenation! 

Understanding Salmon DNA

The salmon DNA molecule is close to human DNA. It is easily absorbed through the skin.  Many dermatologists have now used the product in Europe with great success. At VitaLife-MD our salmon DNA serum is enriched with several ingredients such as hyaluronic acid and proteoglycans, all prepared without any preservatives. This makes the solution a highly moisturizing cocktail that can regenerate the skin and reduce inflammation. 

Potential Benefits

Once injected, the DNA stimulates fibroblasts, which are the cells responsible for producing collagen and elastin. Their production is increased which helps improve skin texture, reduce wrinkles, and tighten sagging skin.  This makes the skin look healthier.

Clinical observations suggest that the Salmon DNA Facial may offer several benefits, including:

  • Enhanced Hydration: Improved moisture retention leading to a more supple complexion.

  • Improved Skin Texture: Reduction in the appearance of fine lines and uneven skin tone.

  • Increased Elasticity: Support for collagen synthesis, potentially resulting in firmer skin.

 

The Procedure

It involves injecting purified DNA extracted from salmon sperm into the skin. It is performed using the French Nappage technique with micro injections distributed all over the face and neck, similarly to the microneedling method. 

The procedure typically takes about 30-45 minutes. Our nurse practitioner Carley Cassity will inject the purified salmon DNA into the desired areas of the face using a fine needle. At the end of the session a hydrating mask infused with peptides will be applied to the face for a few minutes followed by the application of a small layer of bioactive salmon DNA cream.

The side effects are very rare. A few patients might experience mild reactions such as redness, swelling, and bruising at the injection site. These side effects are usually resolved within a few days. 

With minimal downtime and rare side effects, this could be an appealing option for those looking for a non-surgical way to improve skin tone and texture. 

Who May Consider This Treatment?

Anyone seeking to address concerns such as dryness, fine lines, and loss of skin elasticity may find this therapy beneficial. As with any cosmetic procedure, a thorough consultation is essential to determine suitability based on individual skin conditions and health history.

Schedule a Consultation

We invite you to schedule a consultation with our team to explore how the Salmon DNA may support your skin health goals. Our practitioners are dedicated to providing personalized care and will guide you through the process, addressing any questions or concerns you may have.

Dominique Fradin-Read