NMN Supplement Improved Formula!
As the New Year begins, we are all looking for even better health and are ready to implement New Year’s Resolutions.
Encouraging you to implement healthy lifestyle habits is of course the first recommendation that Dr. Dominique Fradin-Read will make.
Following her mission to help everyone reach optimal health, she is always looking for cutting-edge discoveries and natural treatments that can complement good lifestyle habits.
This month she is happy to announce the introduction of 1-MNA (1 MethylNicotinAmide) as a new component of our already well-loved product, NMN. The udpated product will still contain the same amount of NMN and will be improved with a small amount of 1-MNA for even better efficacy.
How 1-MNA works
1-MNA acts by blocking an enzyme called NNMT (Nicotinamide N MethyTransferase) that plays a key role in regulating the level of NAD in the cell. This enzyme is implicated in many cellular processes such as metabolic function, cardiovascular health, brain health and even cancer.
1-MNA binds to a receptor site on the enzyme and reduces its activity, The levels of NAD generated by adding 1-MNA to NMN in the same capsule will then be optimized safely.
Besides its role in NAD production, 1-MNA offers many potential benefits for health.
Benefits as general anti-inflammatory compound
1-MNA plays an important role in reducing systemic inflammation. It decreases levels of reactive oxygen species (ROS) and increases mitochondrial membrane potential.
1-MNA can regulate the inflammation cascade in the body by blocking the Nrf2 and NF-κB pathways which are two important steps in the initiation of the inflammatory process.
CRP levels and other inflammatory markers are substantially reduced as well
1-MNA can protect against liver injury induced by high fatty diets
By neutralizing ROS, MNA helps protect cells from oxidative damage, which is a common feature in many chronic diseases, including diabetes, cardiovascular disorders, and autoimmune conditions or inflammatory bowel diseases that involve chronic inflammation.
Benefits for cardiovascular health
1-MNA increases the production of prostacyclin (PGI2) and Nitric Oxide, both important regulators of the endothelial function and potent agent to improve vascular flow and oxygenation of the tissues.
1-MNA has shown potent anti-inflammatory and anti-thrombotic effecs reducing the risk of thrombosis and cardiovascular events. It inhibits platelets activation that is responsible for clotting
In a study by Mateuszuk et al. (2016), there was strong evidence that this compound protects against atherosclerosis by limiting plaque formation
Benefits on brain health
1-MNA exerts an important role for neuroprotection and has shown potential to slow down cognitive decline in neurodegenerative diseases such as Alzheimer and Parkinson’s
Research demonstrated positive results of 1-MNA to reduce inflammation in the brain by regulating the action of the microglia (the immune cells that protect neurons against infections) and by decreasing the production of proinflammatory cytokines This had a direct effect on apoptosis (neurons death) .
Additionally, 1-MNA protects the brain against mitochondrial dysfunction often caused by toxin exposure or stress.
1-MNA appears as a potent and safe natural supplement that is recommended to everyone who wants to add protection against cognitive decline.
Enhancement of athletic performance and chronic fatigue
Recent studies show that 1-MNA could enhance endurance capacity and improve performance
The production of 1-MNA is activated in the muscles of individuals undergoing high-volume-low-intensity exercise. Therefore, MNAM could be an important energy support for the muscles during exercise improving the induction of lipolysis and gluconeogenesis in the liver and adipose tissues, respectively.
Increased levels of 1-MNA during exercise led the researchers to propose that the consumption of 1-MNA during training, especially endurance training, could boost exercise capacity and improve performance. The review shed light on the potential of 1- MNA as a dietary supplement in sports medicine
1-MNA supplementation significantly improved physical performance in a 6-min walk test and reduced the percentage of patients with severe fatigue after COVID-19. The comprehensive action of 1-MNA may be beneficial for the recovery of patients with persistent symptoms of fatigue and low tolerance to exercise after COVID-19.
Benefits on skin and hair
1-MNA can be helpful to treat inflammatory skin conditions such as acne, rosacea, and contact dermatitis
It has also been used topically to treat skin burns and helped with wound
A pilot study found that a gel containing 0.25% 1-MNA was effective in treating rosacea. The study treated 34 patients with rosacea for four weeks, and 26 patients improved substantially
1-MNA might increase lifespan
A few animal models have shown that the molecule acts at the levels of the sirtuins, a family of enzymes that are involved in lifespan regulation 1-MNA enhances SIRT1 expression and stability.
1-MNA extends lifespan by a second mechanism that generates hydrogen peroxide, which then acts as a signal to promote longevity.
Studies using the nematode Caenorhabditis elegans indicate that 1-MNA supplementation may extend lifespan.
One study found that mice with murine leukemia L1210 that were given 1-MNA daily had a lifespan that was about 50% longer
Another study found that 1-MNA improved the survival of diabetic rats, but the effect was limited to the early stages of diabetes.
More studies will be needed to confirm the benefits of 1-MNA on lifespan in humans.
The new product will be available in late January at our VitaLifeMD office. Please email diana@vitalifemd.com to purchase online.
We wish you all a happy and healthy New Year!